Electrical Dynamics of the Dendritic Space by Sergey Korogod and Suzanne Dumont
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Electrical Dynamics of the Dendritic Space by Sergey Korogod and Suzanne Dumont


Dear Reader,
We invite you to travel in space with us! This will be a very peculiar space: the dendritic space of neurons that is the cosmos for neuroscientists. It is mysterious and practically unexplored like the outer space we glimpse at in the sky. Curiously, we can further extend this analogy: the tools of astronomy can be turned from the sky to the microscope stage to explore shining brain stars, the neurons radiating their dendrites into the surrounding space.

This was performed in the pioneering work by Paul Gogan and co-workers using a modified astronomical camera to image the microstructure of the dendritic membrane during the excitation of single live neurons in culture (see references in Chapter 14). The explorers of the dendritic space still have to invent the appropriate spacecrafts and technologies. As in cosmology, experimentation is limited, and mathematical and computer models are the only way of gaining insight into the nature of the dendritic space. The itinerary of our travel relies on these tools.

We start with a brief historical background to the dendritic problem and describe the origin of the structural data used for further morphometric and computer simulation studies of the dendritic arborizations (Chapters 1 and 2). Chapter 3 describes basic bioelectricity with emphasis on space. We show how charge carriers are separated in space and thus electric fields and currents are created across the neuronal membrane.

An important generalization is that, despite multiplicity and diversity of channel types, the number of different types of current–voltage relations is restricted to three. Chapter 4 recapitulates the cable theory of the dendritic transfer properties with special focus on the terms of the cable equation which determine the electrical communication across the membrane and along the dendritic membrane. This issue is further developed in Chapters 5 and 6, specifying the voltage and current transfer along the dendrites.

We highlight that the transfer maps provide an informative representation of the dendritic electrical structure. Chapters 7 and 8 explain how the electrical structures of an artificial dendritic path and of a branch bifurcation are built and how they indicate electrical relations in different dimensions of the dendritic space that are the proximal-to-distal and the path-to-path relations. Next the critical role of metrical asymmetry of the dendritic branches becomes obvious.

Chapter 9 navigates in the dendritic space of biological neurons and introduces our library of reconstructed cells providing specific examples of metrical asymmetry of complex dendritic arborizations. Chapter 10 explores the electrical structures of single biological dendrites as the basic elements for constructing the whole arborization. Here electrical features related to elementary structural heterogeneities present in random combinations in the biological dendrites are noticeable.

The electrical structures of the whole reconstructed dendritic arborizations of different types of neurons are analyzed and classified in Chapters 11 and 12. Relations of the electrical structures related to size, complexity and asymmetry of the arborizations are explored. Finally, Chapter 13 considers the consequences of morphological and electrical structures of the dendritic arborizations for the generation of output discharge patterns. These spatial–temporal patterns indicate some new emerging rules by which the dendrites govern the whole cell activity.

This book results from more than 15 years of cooperation between French and Ukrainian laboratories: the Unit of Cellular Neurocybernetics of the CNRS in Marseille and the Laboratory of Biophysics and Bioelectronics, Dnipropetrovsk National University and Dnipropetrovsk Division of the International Center for Molecular Physiology, National Academy of Sciences of the Ukraine. It originated in the form of seminars, lectures, published papers and notes for students. We have benefited from innumerable discussions with students and colleagues.

To acknowledge all of them personally is impossible but we wish to thank first our collaborators who have co-authored our published articles and who were directly involved in various aspects of our work at different periods between 1993 and 2007. This book would have never happened without them. In the French team, we are specially grateful to Dr. Cesira Batini and Dr. Ginette Bossavit.

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